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Pal-AHK (Palmitoyl Tripeptide-3) Hair Research

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OCTOBER 04, 2023

Findings from studies conducted on animal models suggest Pal-AHK may promote hair development, protect the skin from symptoms related to aging, and hasten the healing of wounds. Studies conducted in the cosmeceutical sector on Pal-AHK suggest that it may increase collagen synthesis, tighten the skin, and speed up the pace at which skin cells regenerate. [i]

In addition, research on animal models suggests that Pal-AHK may stimulate the formation of fibroblasts, which may speed up the synthesis of extracellular matrix (ECM) in the skin. Because the extracellular matrix, which is dominated by collagen and elastin, also contains many molecules as part of its structure, an increase in the skin’s extracellular matrix may increase the levels of collagen and elastin found in the skin. [ii] Researchers’ findings suggest “it promotes collagen formation via TGF-beta.” As a direct result, the skin may become more resilient and look better. [iii]

Experiments conducted in more depth point to the possibility that Pal-AHK may play an important part in controlling the production of vascular endothelial growth factor (VEGF). The signaling molecule, VEGF, plays an important role in forming new blood vessels. Following the presentation of the Pal-AHK peptide, investigations conducted on animal models suggested better skin regeneration and hair growth. This lends credence to the hypothesis that the Pal-AHK peptide may stimulate the development of new blood vessels in the skin. The possibility that Pal-AHK (Palmitoyl Tripeptide-3) may stimulate the synthesis of VEGF may make it possible for the skin to get sufficient blood flow. Studies suggest that this, in turn, may result in increased skin elasticity and tightness. 

Diabetes, cancer, and macular degeneration are just a few disorders linked to VEGF’s activities. It is a kind of angiogenic factor that governs the process of angiogenesis by making it possible for endothelial cells to proliferate, migrate, and be permeable. Therefore, the potential capacity of Pal-AHK to commence the augmentation of VEGF production may aid in the prevention of the prevalence of diseases such as diabetes, cancer, and macular formation, in addition to possibly mitigating certain diseases that affect the cardiovascular system.

It is possible that wound healing might proceed more quickly if Pal-AHK is introduced. Researcher suggest the peptide may speed up the synthesis of the growth factor VEGF [iv]. The study’s findings suggest Palmitoyl tripeptide-3 “mimics the effects of an extracellular matrix protein called thrombospondin-1 (TSP-1),” a naturally occurring molecule that amps up the activity of TGF. TSP-1 has been suggested to promote faster healing of wounds locally in animal models and dermal fibroblast cell culture studies.

The deposition of collagen at the site of damage, together with angiogenesis and epithelization, may enable such a result. Researchers even go so far as to say VEGF’s chemotactic, mitogenic, and permeability effects may be powerful enough to promote repair and regeneration in non-healing wounds associated with artery occlusive disease and diabetes. This may be the case because VEGF has the potential to attract and activate chemotactic receptors on cells. Even though these studies found that very few subjects experienced full restoration of eyesight, scientific investigations suggest that the capacity of Pal-AHK to stimulate the production of VEGF may also help bring about visual improvement to a minor degree. On average, subjects saw an improvement of roughly two lines of vision.

Pal-AHK, Wrinkles, and Hair Growth

Research on animal models using Pal-AHK has suggested that it may have a significant promise for mitigating wrinkle development in skin. It has been hypothesized that exposure to AHK in a laboratory environment may increase collagen production in skin cells. Research suggests AHK may be a possible fibroblast stimulant and as a result, it has been the subject of much research. It has been observed that incorporating palmitoyl into AHK may increase AHK activities, which is observed in skin penetration and cell membranes, among other things. Consequently, there is a possibility that the levels of collagen production and the effects of collagen itself may rise. 

Additional study in animal models suggests that Pal-AHK may diminish and block the prevalence of fine lines and wrinkles, restrict the emergence of age-related spots, include skin tone, enhance texture, and increase skin smoothness. More research is being reviewed in this area.

Researchers speculate Pal-AHK may also have a part in lowering oxidative stress, commonly known as free radical assault, and boosting hair development in the dermal cells of the papilla. Its alleged capacity to alleviate oxidative stress may induce increased production of DHT in the scalp follicles. It would seem that the AHK complex may suppress oxidative stress by increasing the production of the enzyme superoxide dismutase (SOD). This, in turn, may neutralize the highly reactive free radical superoxide. The effects of AHK have been observed by researchers to be improved upon by including palmitoyl as part of the peptide sequence.

Scientists hypothesize Pal-AHK (Palmitoyl Tripeptide-3), also known as Palmitoyl Tripeptide-3, may possibly stimulate hair growth, combat the symptoms of skin aging, and hasten the healing of wounds. Research done recently in the field of cosmetics lends credence to the idea that this peptide may also serve to tighten the skin, boost the creation of collagen, and quicken the pace at which the skin regenerates itself. This peptide is not intended for human use or ingestion and should only be used for educational and research purposes. If you are a researcher, visit Core Peptides to find Pal-AHK for sale.


[i] Lubkowska, Beata & Grobelna, Beata & Maćkiewicz, Zbigniew. (2010). The use of synthetic polypeptides in cosmetics. Copernican Letters. 1. 75. 10.12775/CL.2010.010.

[ii] Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009 Oct;31(5):327-45. doi: 10.1111/j.1468-2494.2009.00490.x. Epub 2009 Jun 30. PMID: 19570099.

[iii] Lourith N, Kanlayavattanakul M. Biopolymeric agents for skin wrinkle treatment. J Cosmet Laser Ther. 2016 Oct;18(5):301-10. doi: 10.3109/14764172.2016.1157369. Epub 2016 Apr 22. PMID: 26963365.

[iv]  Schagen, Silke Karin. “Topical peptide treatments with effective anti-aging results.” Cosmetics 4.2 (2017): 16

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OCTOBER 04, 2023